Perineural injection therapy (PIT), also known as neural prolotherapy or perineural injection treatment, is a relatively new approach to pain management. It involves injecting a dextrose (sugar water) solution near nerves to reduce pain and inflammation. This technique is based on the theory that many chronic pain conditions are caused by inflammation and irritation of peripheral nerves.

During a perineural injection procedure, a small needle is used to inject the dextrose solution into the tissue surrounding a nerve. The goal is to "reset" the nerve and reduce its sensitivity to pain signals. This technique is often used to treat conditions such as nerve pain, neuropathy, and musculoskeletal pain.